Prokaryotic cell Eukaryotic cell
Most prokaryotes are uni-cellular. Most eukaryotes are multi-cellular.
Size of the cell is generally small (0.5- 5 µm). Size of the cell is generally large (50- 100 µm).
Nuclear region is poorly defined due to the absence of a nuclear membrane or the cell lacks true nucleus. Nuclear region is well-defined and is surrounded by a nuclear membrane, or true nucleus bound by a nuclear membrane is present in the cell.
It contains a single chromosome. It contains more than one chromosome.