Question

How is oxaloacetate regenerated to complete the TCA Cycle?

Answer 1

Regeneration of oxaloacetate:

1. Oxaloacetate is a four-carbon organic molecule produced at the last step of the Krebs cycle (TCA cycle).
2. TCA cycle helps to produce energy-rich molecules such as ATP, NADH, etc., for fulfilling the energy requirements of the cell.
3. Oxaloacetate is generated by the enzyme malate dehydrogenase from the substrate malic acid.
4. One molecule of NADH is produced in this reaction from the reduction of the NAD⁺ molecule.