1. Amoeba and paramecium both are heterotrophs.
2. Amoeba moves by using pseudopodia while the locomotion of paramecium is performed using cilia.
3. Amoeba can change its body shape, whereas paramecium does have a definite shape like the sole of a shoe.
4. Amoeba feeds through phagocytosis, while paramecium feeds itself through predation.