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Question

Identify the DNA segment that is not a palindromic sequence

A
5' GAATTC 3' 3' CTTAAG 5'
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B
5' CCCGGG 3' 3' GGGCCC 5'
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C
5' GGATCC 3' 3' GGTACC 5'
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D
5' GCGGCCGC 3' 3' CGCCGGCG 5'
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Solution

The correct option is C 5' GGATCC 3' 3' GGTACC 5'
A palindromic sequence is a nucleic acid sequence that is the same whether read from 5'-3' direction on the strand or 3'-5' direction on the complementary strand of which each forms a double helix. They are basically inverted repeats of nucleotides on dsDNA or the restriction sites of restriction endonucleases.
5' GGATCC 3' is not palindromic to 3' GGTACC 5'.

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