The correct option is D They are not sensitive to heat.
Enzymes are biological catalyst which catalyze biological reactions. Most of the enzymes are proteins in nature. Some of the enzymes have non protein part which helps them to carry out reaction. Enzymes change the rate of chemical reaction by bringing about a decrease in free energy requirement. Thus, changing the free energy of the reaction. Because enzymes are proteins, they are highly sensitive to heat. Thus, enzymes catalyze reactions only at physiological conditions of temperature and pH.