Identify the triplet code for valine that replaces glutamic acid in hemoglobin & leads to sickle cell anemia.

GTA

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GTG

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GTT

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GTC

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Solution

The correct option is B GTG
Sickle cell anemia is caused by a point mutation at the 8th position of the beta-globin chain of haemoglobin.
Normal beta haemoglobin chain contains glutamic acid at the 8th position while in sickle cell anemia, it has valine. The normal chain is coded by the sequence GAG which becomes GTG in sickle cell anemia patients.
So, the correct option is 'GTG'.

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In sickle cell anaemia, glutamic acid is replaced by valine. Which one of the following triplets codes valine?

β

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