Question

Identify the tumour suppressor genes from the following.

• A. $P^{53}$ genes
• B. Pseudogenes
• C. SRY genes
• D. Oncogenes

Answer 1

Answer: (A)

$P^{53}$ genes

Tumor suppressor genes encode the proteins that prevent the cell to progress through the cell cycle and their inactivation causes tumor formation. $p^{5}3$ genes encodes a protein that arrests the cells having damaged DNA in $G_1$ and $G_2$ phases of cell cycle. An imperfect copy of a working gene is called as a pseudogene. SRY gene is present on Y chromosome and is responsible for the development of testis in human males; absence of this gene in females determines feminism. Any gene that encodes a protein capable of cell transformation in culture or induction of cancer in animals is referred to as an oncogene. Thus, the correct answer is option A.