If a circle passes through the point (1, 2) and cuts the circle x2+y2=4 orthogonally, then the equation of the locus of its centre is
2x + 4y - 9 = 0
Let equation of circle be x2+y2+2gx+2fy+c=0
It passes through (1, 2) i.e. 1 + 4 + 2g + 4f + c = 0 and is orthogonal w.r.t x2+y2=4.
Therefore, 2g × 0 + 2f × 0 = -c + 4 or c = 4
Hence, we get 2g + 4f + 9 = 0,
then 2x + 4y - 9 = 0 is the required locus.