If a person drinks large amounts of water in a short period of time, he may die of water toxicity. ADH can help prevent water retention by interaction with target cells in
Kidney
The hypothalamus produces a hormone known as antidiuretic hormone (ADH), which is transported to and released from the posterior pituitary gland. The principal action of ADH is to regulate the amount of water excreted by the kidneys. As ADH which is also known as vasopressin causes direct water reabsorption from the kidney tubules, salts and wastes are concentrated in what will eventually be excreted as urine. When ADH is absent, the kidneys do not retain water and excessive quantities of urine are produced.