Question

If DNA codons are ATG GAA, insertion of the thymine after the first codon results in,

• A. Non-sense mutation
• B. Mis-sense mutation
• C. Frameshift mutation
• D. Silent mutation

Answer 1

The correct option is C Frameshift mutation

A frameshift mutation is a mutation which shifts the group of bases so the frame in which it is read is disturbed. It takes place due to insertion or deletion of nucleotides.Mutation due to insertion of base thymine in between the DNA codon will alter the way in which the template reads. If T is inserted in between it will read by polymerase as ATGTGAA. So the whole reading frame is disturbed. Thus, the correct answer is option C.