Question

If for some reason the parietal cells of the stomach epithelium become partially non-functional, what is likely to happen?

• A. Steapsin will be more effective
• B. The pH of stomach will fall abruptly
• C. The pancreatic enzymes and specially the trypsin and lipase will not work efficiently
• D. Proteins will not be adequately hydrolysed by pepsin into proteoses and peptones

Answer 1

The correct option is D

Proteins will not be adequately hydrolysed by pepsin into proteoses and peptones

The correct option is D:

Explanation of the correct option:

1. The stomach contains parietal cells. HCl and Castle Intrinsic Factor are produced by these cells.
2. The oxyntic cells are also known as parietal cells. They're also referred to as delomorphous cells on occasion.
3. Gastric juice contains a significant amount of hydrochloric acid. It renders the medium acidic and keeps the pH between 1.5 and 3. It prevents germs and bacteria from flourishing in the stomach's environment.
4. The gastric juice's pepsinogen enzyme is activated by hydrochloric acid. It transforms pepsinogen into pepsin.
5. The main proteolytic enzyme in the stomach is pepsin. This means that it causes the proteins in the stomach to lyse, or break down. Proteases and peptones are formed once the proteins are hydrolyzed.
6. Proteins will not be effectively digested by pepsin into proteases and peptones if the parietal cells of the stomach epithelium become partially non-functional for some reason.

Explanation of the incorrect option:

Option A:

1. The enzyme lipase is also known as steapsin.
2. Lipase is largely synthesised in the pancreas rather than the parietal cells.

Option B:

1. The parietal cells are in charge of creating hydrochloric acid, which keeps the pH between 1.5 and 3.
2. If parietal cell becomes non functioning then the pH of the stomach will increase.

Option C:

1. Our stomach acids encourage the production of bile from the liver and gallbladder, and HCL also stimulates the release of digestive enzymes from the pancreas
2. Bile is necessary for protein digestion. This is a proteolytic enzyme that is required for proper protein metabolism in the human body.
3. Non-functional parietal cell will not affect the functioning of trypsin and lipase.

Final answer: If for some reason the parietal cells of the stomach epithelium become partially non-functional then proteins will not be adequately hydrolysed by pepsin into proteoses and peptones.