If immunoglobulin IgG was papain digested, which of the following parts of it can not be observed in the screening
I. Fab
II. Fc
III. F(ab) $_{2}$

I and II

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II and III

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III only

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II only

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Solution

The correct option is C III only
If IgG is subjected to papin digestion- 2 identical Fab fragments, which are monovalent in nature and 1 Fc regions are obtained.
In contrast, divalent antibody fragments F(ab)2 are generated by pepsin digestion, not papain.

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