Question

If in a man, normal glucose conc. increases to 190 mg/100 ml. Which of the following will occur?

• A. Extra glucose will get deposited in form of ketone bodies.
• B. Extra glucose is changed to glycogen and get stored in liver.
• C. Extra glucose will be excreted by kidney.
• D. All of the above.

Answer 1

The correct option is D All of the above.

The blood glucose level in body is tightly regulated by a number of mechanism. The normal blood glucose level in humans should not exceed 140 mg per decilitre after meals and is maintained between 70 to 100 mg per decilitre under fasting conditions without food. Glucose is a precious metabolite and, hence, is actively reabsorbed by the kidney tubules. Any excess quantity of glucose is converted into glycogen which is stored in liver and muscles. Any further excess is converted to fats and stored for long term deposit. In humans and most other mammals, acetyl CoA formed in the liver during oxidation of fatty acids may enter the citric acid cycle or may be converted to ketone bodies, i.e., acetoacetate, $\beta$-hydroxy-butyrate and acetone for export to other tissues. Overproduction of ketone bodies can occur in conditions of severe starvation and in uncontrolled diabetes.