Total number of subsets = 12C4=495
Now, find the subsets where the selected 4 numbers are non-consecutive.
For each such case, the non-consecutive numbers occupy any four of the gaps created by remaining 8 natural numbers.
Total number of gaps formed by 8 numbers is 9.
So the number of solutions is equivalent to filling any 4 out of 9 gaps obtained. This can be done in 9C4=126 ways.
Hence, the number of subsets where atleast two numbers are consecutive is 495−126=369