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Question

If somatic cells of a human male contain a single Barr body, the genetic composition of the person would be

A
XXY
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B
XXX
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C
XO
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D
XXXY
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Solution

The correct option is A XXY
Human females contain two X chromosomes as compared to one X chromosome in males. This gives the potential to produce twice the gene product as compared to males.
A mechanism operates here to solve the problem called dosage compensation.
In humans, dosage compensation is achieved by the inactivation of one X chromosome in the female somatic cells. This inactivated chromosome is known as the Barr body.
The number of Barr bodies is one less than the number of X-chromosomes. So, if the somatic cells of a human male contain a single Barr body, the genetic composition of the person would be XXY.

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