Question

If the father has autosomal dominant disease, then what will be the probability of having an affected offspring irrespective of sex of the child, if the mother is unaffected?

• A. 90%
• B. 10%
• C. 50%
• D. 100%

Answer 1

The correct option is C 50%

In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes).
Only one mutated gene is necessary to be affected by this type of disorder. A person with an autosomal dominant disorder — in this case, the father — has a 50% chance of having an affected child with one mutated gene (dominant gene) and a 50% chance of having an unaffected child with two normal genes (recessive genes) irrespective of the sex of the child.