Evolution. Lamarck is best known for his Theory of Inheritance of Acquired Characteristics, first presented in 1801 (Darwin's first book dealing with natural selection was published in 1859): If an organism changes during life in order to adapt to its environment, those changes are passed on to its offspring.
Lamarck's Theory of Inheritance of Acquired Characteristics has been disproved. This was done in two major ways. The first is by experiment. We have seen through many real examples and observations that changes that occur in an animal during life are not passed on to the animal's offspring.
But if it was true then the handicapped parent produces a handicapped offspring and we would have developed immunity for various diseases from parents.