Question

Illustrate on Human Genome project (HGP) and the methods used for the study.

Answer 1

• The HGP is a large effort to trace the genetic make up of genome of humans and other oragnisms. The complete architecture of human genome has been traced through studies during this project. HGP provides a detailed knowledge about the human DNA its composition , make up and the whole information to benefit biomedical field.
• HGP involved two major approaches: Expressed Sequence Tags (ESTs) – This approach focussed on identifying all genes expressed as RNA. Sequence Annotation – This blind approach involved sequencing the whole genome (coding and non-coding) and later assigning functions to the different regions.