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Question
Immunosuppressive drugs like cyclosporine delay the rejection of graft post organ transplantation by
Immunosuppressive drugs like cyclosporine delay the rejection of graft post organ transplantation by
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Solution
The correct option is C Inhibiting T cell infiltration
Cyclosporine (Cs) is an immunosuppressive drug which helps in delay the rejection of graft post-organ transplantation. It inhibits the gene encoding IL-2 and high-affinity receptor IL-2 which is responsible for the activation of T cells. Cyclosproine drugs bind with the multifunctional cytoplasmic protein and form a complex called immunophilins or cyclophins which block the phosphatase activity of calcineurin then it suppresses DNA binding protein which is responsible for the activation of T cells. It also inhibits the T helper cell proliferation and infiltration. Thus, the correct answer is option A
Cyclosporine (Cs) is an immunosuppressive drug which helps in delay the rejection of graft post-organ transplantation. It inhibits the gene encoding IL-2 and high-affinity receptor IL-2 which is responsible for the activation of T cells. Cyclosproine drugs bind with the multifunctional cytoplasmic protein and form a complex called immunophilins or cyclophins which block the phosphatase activity of calcineurin then it suppresses DNA binding protein which is responsible for the activation of T cells. It also inhibits the T helper cell proliferation and infiltration. Thus, the correct answer is option A
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