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Question

In a given DNA segment ATG ACC AGG ACC CCA ACA, the first base gets mutated through silent substitution. The effect of this on coding by this DNA segment will result in

A
Complete change in the type as well as sequence of amino acids
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B
Change in the first amino acid only
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C
No change in the sequence
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D
One amino acid less in the protein
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E
No coding
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Solution

The correct option is C Change in the first amino acid only

Mutations range in size and can effect a single DNA base pair or a large segment of a chromosome(multiple genes). At the DNA level, the mutations which are mostly point mutations are either base substitutions, base additions or deletions. In the given DNA segment ATG ACC AGG ACC CCA ACA, the first base gets mutated through silent substitution, one codon of amino acid changes for another codon of same amino acid. However, in the case of a missense mutation, one codon of the amino acid is replaced by codon of another amino acid. However, in both cases, only the first amino acid will change. Thus, the correct answer is option B.


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