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Question
In a man, huge hand and legs are due to the abnormal secretion of
In a man, huge hand and legs are due to the abnormal secretion of
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Solution
The correct option is C GH
Excess GH production is most often caused by a benign tumour (adenoma) of the somatotroph cells of the pituitary gland. In some cases, a tumour of the lung or of the pancreatic islets of Langerhans produces GHRH, which stimulates the somatotrophs to produce large amounts of GH. In rare cases, ectopic production of GH (production by tumour cells in tissues that do not ordinarily synthesise GH) causes an excess of the hormone. Somatotroph tumours in children are very rare and cause excessive growth that may lead to extreme height (gigantism) and features of acromegaly. Acromegaly refers to the enlargement of the distal (acral) parts of the body, including the hands, feet, chin, and nose. The enlargement is due to the overgrowth of cartilage, muscle, subcutaneous tissue, and skin.
Therefore, the correct answer is option C.
Excess GH production is most often caused by a benign tumour (adenoma) of the somatotroph cells of the pituitary gland. In some cases, a tumour of the lung or of the pancreatic islets of Langerhans produces GHRH, which stimulates the somatotrophs to produce large amounts of GH. In rare cases, ectopic production of GH (production by tumour cells in tissues that do not ordinarily synthesise GH) causes an excess of the hormone. Somatotroph tumours in children are very rare and cause excessive growth that may lead to extreme height (gigantism) and features of acromegaly. Acromegaly refers to the enlargement of the distal (acral) parts of the body, including the hands, feet, chin, and nose. The enlargement is due to the overgrowth of cartilage, muscle, subcutaneous tissue, and skin.
Therefore, the correct answer is option C.
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