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Question

In blood (pH=7.4), aspirin has pKa of 3.4. What is the ratio of A to HA?

A
1:10000
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B
1000:1
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C
10000:1
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D
100:1
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Solution

The correct option is C 10000:1
Given, pKa=3.4, pH=7.4
Using Henderson-Hasselbalch equation:
pH=pKa+log([conjugate base][acid]
pH=pKa+log([A][HA]
7.4=3.4+log([A][HA])
7.4=3.4=log([A][HA]
4=log([A][HA]
104=[A][HA]
[A]:[HA]=10000:1

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