In feedback inhibition, a metabolic pathway is switched off by

Lack of a substrate

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Accumulation of the end product

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A rise in temperature

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Competitive inhibition

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Solution

The correct option is A Accumulation of the end product
Accumulation of the end product triggers inhibition or switching off of the metabolic pathway in feedback inhibition mechanism.
So, the correct option is 'Accumulation of the end product'.

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