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Question

In guinea pigs, short coat is dominant to long.
If a breeder wants to ensure that the short-haired guinea pig he has is homozygous for the hair length trait and could not afford genetic testing, which plan would be the best possible choice to give him this information?

A
Breed the animal with one that is homozygous for long hairless and watch for long hair offspring.
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B
Breed the animal with one that is heterozygous for short hair and watch for long hair offspring.
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C
Breed the animal with one that is heterozygous for short hair and watch for short hair offspring.
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D
Breed the animal with one that is homozygous for long hairless and watch for short hair offspring.
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Solution

The correct option is D Breed the animal with one that is homozygous for long hairless and watch for short hair offspring.
In the guinea pig, short coat (C) is dominant to long coat (c). Guinea pig with genotype cc will have long hair. However, a guinea pig with short hair would have either genotype Cc or cc. To confirm the homozygosity of short-haired guinea pig, the breeder must do test cross. In test cross, the animal whose genotype is not known is bred with the animal having a homozygous recessive trait. In the given case, short-haired guinea pig (CC/Cc) can be bred with long-haired guinea pig (cc). If this produces both short haired (Cc) and long-haired (cc) progeny, then the short haired guinea pig will be heterozygous. If this produces only short haired (Cc) progeny, then the short haired guinea pig will be homozygous.
Thus, the correct answer is 'Breed the animal with one that is homozygous for long hairless and watch for short hair offspring.'

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