In humans, Philadelphia chromosome is formed by reciprocal translocation between chromosomes.
A
9 and 21
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B
9 and 22
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C
9 and 20
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D
20 and 10
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E
3 and 11
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Solution
The correct option is B9 and 22
The Philadelphia chromosome is a reciprocal translocation involving chromosomes 9 and 22 that is commonly identified in chronic myelogenous leukemia (CML). The break points of the translocation create a fusion of two genes: ABL1 on chromosome 9 and BCR on chromosome 22.