Question

In immunoglobulin ,disulphides do not join

• A. Two heavy chains
• B. Light chain with heavy chain
• C. Two light chains
• D. All the above

Answer 1

The correct option is C Two light chains

• Each IgG contains a total of 12 intra-chain disulfide bonds.
• Each disulfide bond is associated with an individual IgG domain.
• The light chain of the IgG1 is connected to the heavy chain by a disulfide bond between the last cysteine residue of the light chain and the fifth cysteine residue of the heavy chain. And also between the two heavy chains.
• Hence, In immunoglobulin, disulphides do not join Two light chains.
• So, the correct answer is 'Two light chains'.