In large doses, analgesics that work in the brain as antagonists to certain chemicals have caused psychological disturbances in patients, which may limit their potential to relieve severe pain.
An effect that may limit the potential of such analgesics for relieving
Option: (D)
In option A, which is modifying patients in place of psychological disturbances.
In option B, which is modifying patients in place of psychological disturbances.
We have to choose between Option C and D.
In option D, "thier" is ambiguous and could refer back to patients or anlalgesics thus making it an incorrect option.