The correct option is A Permeability, which becomes very low.
Collagen is the main structural component of the various connective tissues in the animals. As we age, the collagen levels decrease, showing more signs of aging.
Initially, collagen is permeable, soluble and flexible; so there is easy exchange of material between the cytoplasm and interstitial fluid. But with age, collagen becomes less permeable, less flexible. Hence, activity of collagen is affected.
Thus, the correct answer is option (A), 'Permeability which becomes very low'.