Question

In plasma membrane will the extrinsic and intrinsic proteins be attached together?

Answer 1

In plasma membrane, extrinsic and intrinsic proteins are attached to each other. Intrinsic proteins have one or more fragments embedded in the phospholipid bilayer. Peripheral proteins do not interact with the hydrophobic core of phospholipid bilayer. Instead they usually bound indirectly by interacting with intrinsic membrane proteins or directly with lipid polar group.