Question

In post-transcriptional modification, 5’ capping and 3’ polyadenylation is important for
(A) Protection of mRNA
(B) Transport of mRNA from the nucleus to the cytoplasm
(C) Increase the stability of mRNA
(D) Decrease the half-life in order to control the gene expression

Choose the correct option

• A. A,C,D
  
• B. A,B,C
• C. A,B,D
• D. B,D,C

Answer 1

The correct option is B A,B,C

The addition of methyl guanosine triphosphate at the 5’ end of hnRNA is known as 5’ capping, it helps to protect the mRNA from degradation, and transport from the nucleus to the cytoplasm. At the same time addition of poly(A) tail at the 3’ end is known as polyadenylation, which will increase the stability of the mRNA and serve as a recognitional signal for the binding of translation factors. Capping at 5’and poly(A) tail at 3’ end are interdependent and they generally increase the half-life of an mRNA.