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Question

In presence of malonate, which step in the kreb cycle will be inhibited?


A

Malate to oxaloacetate

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B

Alpha ketogluterate to succinyl co-A

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C

Succinate to fumerate

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D

Citrate to alpha keto gluterate

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Solution

The correct option is C

Succinate to fumerate


Malonate inhibits succinate dehydrogenase which helps in conversion of succinate to fumerate. Hence the step involving conversion of succinate to fumerate will be blocked.


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