In reversed-phase chromatography, the hydrophobic stationary phase is used. Which of these silica-based compounds can be used as a stationary phase?

Cyano bonded silica

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Phenyl bonded silica

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Octadecyl (

C - 18

) carbon chain bonded silica

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All of these

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Solution

The correct option is D All of these
In reversed phase chromatography, the stationery phase is hydrophobic in nature.
In the above mentioned options, cyano group, phenyl group and $C - 18$ carbon chain all are hydrophobic in nature. Their interaction with water is not at all good. And hence, being hydrophobic, they can be used as a stationery phase in reversed phase chromatography`.

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