Question

In sickle cell anaemia glutamic acid is replaced by valine. Which one of the following triplets codes for valine?

• A. G A A
• B. G U G
• C. A A G
• D. G G G

Answer 1

The correct option is B G U G

Sickle cell anaemia:

Sickle-cell anaemia is inherited in an autosomal recessive pattern. In this disorder, a mutated form of haemoglobin distorts the red blood cells into a crescent shape (sickle shape) at low oxygen levels.



In sickle cell anaemia glutamic acid is replaced by valine at the sixth position in the beta chain of globin molecules. It occurs when GAG is replaced by GUG.



GGG Code:

Triplet code GGG codes for amino acid glycine.

AAG Code:

Triplet code AAG codes for amino acid lysine.

GAA code:

Triplet code GAA codes for amino acid glutamate.

GUG code:

Triplet code GUG codes for amino acid valine.

Final answer :
d.) GUG

Summary:

Sickle-cell anaemia:

Sickle-cell anaemia is inherited in an autosomal recessive pattern. In sickle cell anaemia, glutamic acid is replaced by valine at the sixth position in the beta chain of globin molecules. It occurs when GAG is replaced by GUG.


Final answer :
d.) GUG