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Question

In urea cycle, urea is produced directly from

A
ammonia
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B
arginine
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C
fumarate
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D
none of the above
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Solution

The correct option is B arginine
In the first step, ammonia and carbon dioxide combine to enter the urea cycle. Ornithine along with another intermediate forms citrulline. Citrulline binds to aspartate, and after a couple of steps arginine is formed; in the process fumarate is released. Arginine is converted to ornithine, in which reaction water is used up and urea is produced. The ornithine regenerated in this step again takes part in the cycle.
So, urea is directly produced from arginine.

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