In Interphase, the chromosomes are in the form of chromatin i.e they are not condensed to form chromosomes. Chromatin consists of DNA and histone proteins. The DNA (negatively charged) winds around histone octamer (positively charged) to form nucleosome. One nucleosome has approx. 200 bp of DNA. Nucleosomes in a chromatin resemble beads present on strings. Beads on string structure in chromatin are further packaged to form chromatin fibres, which further coil and condense to form chromosomes which occurs in metaphase.