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Question
In which of the following organelle the MHC II molecule gets assembled before exogenous antigen processing?
In which of the following organelle the MHC II molecule gets assembled before exogenous antigen processing?
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Solution
The correct option is B Endoplasmic reticulum
In the endoplasmic reticulum, during synthesis of class II MHC, the α and β chains are produced and complexed with a special polypeptide called invariant chain. The nascent MHC class II protein has its peptide-binding cleft blocked by the invariant chain to prevent it from binding cellular peptides or peptides from the endogenous pathway. The chain also aids the export of class II MHC from the Endoplasmic reticulum to the Golgi, followed by fusion with a late endosome containing endocytosed, degraded proteins. Thus the correct answer is option B.
In the endoplasmic reticulum, during synthesis of class II MHC, the α and β chains are produced and complexed with a special polypeptide called invariant chain. The nascent MHC class II protein has its peptide-binding cleft blocked by the invariant chain to prevent it from binding cellular peptides or peptides from the endogenous pathway. The chain also aids the export of class II MHC from the Endoplasmic reticulum to the Golgi, followed by fusion with a late endosome containing endocytosed, degraded proteins. Thus the correct answer is option B.
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