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Question

In which of the following steps of citric acid cycle, CO2 is evolved?
I. Citric acidαketoglutaric acidII. Succinic acidMalic acidIII. Malic acidOxaloacetic acidIV. αketoglutaric acidSuccinyl CoA
Select the correct answer using the codes given below

A
I and II
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B
I and IV
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C
II and III
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D
II and IV
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E
III and IV
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Solution

The correct option is B I and IV
Citric acid cycle or Krebs, cycle is the process where pyruvate (reduced from glycolysis) is broken down into CO2 and water. It takes place in the mitochondrial matrix of the cell. During citric acid cycle, the steps where CO2 is evolved are:
(i) During the formation of α-ketoglutaric acid (5C) from citric acid (6C) with the formation of NADH+H+ from NAD+.

(ii) During the formation of succinyl Co-A (4C) from α-ketoglutaric acid (5C) with the formation of NADH+H+.

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