Question

In which reactions, product formation takes place according to Hofmann's rule?

• A.
• B.
• C.
• D.

Answer 1

Answer: (A), (C), (D)

Hofmann product is the lease substituted alkene product.
Generally, Hofmann product is the major product when bulky base is used or when the leaving group in E2 is poor.

In (A), the base used is bulky so it will give hofmann product.

(A)
In (C) and (D), we have a poor leaving group ${}^{+}N{R}_3$ and ${}^{+}S{R}_2$. Hence, they will give hofmann product.

(C)
(D)

In (B), we get saytzeff product, because the base is not bulky and substrate has a good leaving group (Br).