Question

In which stage of the cell cycle histone proteins synthesized in a eukaryotic cell?

• A. During $G_2$ stage of prophase
• B. During S-phase
• C. During entire prophase
• D. During telophase

Answer 1

Answer: (B)

During S-phase

During the S phase or synthetic phase of interphase, replication of DNA and synthesis of histone proteins occur. New histones are required in massive amounts immediately at the beginning of the S period of DNA synthesis to provide the new DNA with nucleosomes.

So, the correct option is 'During S-phase'.