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Question

Inadequate protein intake leads to Kwashiorkor. The subsequent edema is most closely related to inadequate synthesis of which protein?

A
Gamma globulin
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B
Glucagon
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C
Insulin
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D
Albumin
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Solution

The correct option is D Albumin
Kwashiorkor is associated with a decrease in serum proteins. The drop is particularly striking in liver-synthesized protein i.e. albumin ( < 2 g/dl against 3-4.5 g/dl ) and lipoproteins. The protein synthesis in liver is dependent upon the supply of alimentary amino acids after each meal. So later if the protein deficiency persist there is again a drop in the level of albumin synthesis which can be noticed immediately.
The ingestion of protein rich food can control kwashiorkor. The treatment can be monitored by measuring plasma albumin concentration, disappearance of edema and gain in body weight.

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