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Question

Increase of oxyhaemoglobin leads to increase in acidic nature of blood. This is

A
Bohr's effect
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B
Hamburger phenomenon
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C
Chloride shift
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D
Haldane effect
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Solution

The correct option is C Haldane effect
The Haldane effect is the property of haemoblogin in which deoxygenated haemoglobin has a higher affinity for CO2 than does oxyhaemoglobin because it is a better proton acceptor than oxyhaemoglobin. Therefore, when haemoglobin is deoxygenated (i.e., at tissues) there is a right shift of the carbonic acid-bicarbonate buffer equation to produce H+, which in turn increases the amount of CO2, which can be carried by the blood back to the lungs to be exhaled. Then, with oxygenation at the lungs CO2 dissociates more readily from haemoglobin.

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