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Question

Interferons are good agents to fight against cancerous cells because __________________.

A
these glycoproteins are used to directly kill the infected cells
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B
these glycoproteins send signals to the neighbouring uninfected cells to destroy the RNA and attract immune cells
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C
these glycoproteins lowers the immune system activity to target the cancerous cells
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D
these glycoproteins avoids detection and destruction of cancerous cells by the immune system.
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Solution

The correct option is B these glycoproteins send signals to the neighbouring uninfected cells to destroy the RNA and attract immune cells

Cancer is a term used for the diseases, in which abnormal cells divide without control and invade nearby tissues. There are various methods used for the treatment of cancers.

Immunotherapy is one of the treatment method against cancers. Man made α-interferons are used against cancer cells in immunotherapy.

Interferons are glycoproteins produced by the virus infected cells. They interfere with the multiplication of viruses in the cells. These glycoproteins are part of natural defenses to target the germs or cancer cells by triggering the immune cells (macrophages, natural killer cells) to fight against them. Interferon shots are given under the skin or into muscle.

Interferons work in different ways :
  • They alert the immune system to recognise and attack the virus or cancer cells. Interferons are not used directly to kill the infected cells. Hence option a is incorrect.
  • They stimulate the immune system to develop T cells to act against cancerous cells. T cells are a type of white blood cells that fight against diseases and infections. In this way interferons increases the immune system activity to target the cancerous cells. Hence option c is incorrect.
  • They stop viruses and cancerous cells from growing and dividing. Interferons signal the neighbouring uninfected cells to destroy the RNA and attract other immune cells. Hence option b is correct.
  • They encourage cancer cells to release chemicals that attract immune cells (macrophages, natural killer cells). In this way they helps in increasing detection and destruction of cancer cells by the immune system. So option d is incorrect.
  • They slow the growth and spread of cancerous cells.
Figure : Mechanism of action of α-interferons



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