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Question

Introduction of the correct version of the defective genes in all the growing cells of the individual can be achieved by ________.

A
germ line therapy
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B
somatic cell therapy
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C
gene augmentation therapy
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D
corrective gene therapy
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Solution

The correct option is A germ line therapy

In germ line gene therapy DNA is transferred into the germ cells which tend to produce reproductive cells- eggs or sperm. This therapy allows for the correction of disease causing gene variants that can be passed from one generation to another.

Somatic cell therapy can be defined as a correction method for the genetic disorder in which a normal gene is inserted into appropriate cells (lungs cells, blood cells, skin cells) of an affected individual thus altering the gene expression to produce therapeutic effect.

In gene augmentation therapy, simple addition of functional alleles is used to treat inherited disorders caused by the genetic deficiency of gene products.

The theory of corrective gene therapy is also called gene replacement therapy. In this process, specific gene mutation like in tumor cells, is rectified by using a retroviral vector which introduces a normal copy of the gene back into the tumor.


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