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Question

Introduction of the remedial gene into the cells of the bone marrow falls under _________.

A
Germ line gene therapy
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B
Somatic cell gene therapy
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C
Both a and b
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D
Ex-vivo cell gene therapy
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Solution

The correct option is B Somatic cell gene therapy

Somatic cell gene therapy is defined as the process of introducing a genetic material in the form of RNA inside the appropriate cell (bone marrow in this case) in such a manner that it controls the cell’s mechanism of gene expression, so that it can produce the required therapeutic effect. Somatic cell gene therapy can cure a disease only in the patient, and not to their offsprings.

In germ line gene therapy DNA is transferred into the germ cells which produce the reproductive cells- eggs or sperm, in the body. This therapy allows for the correction of disease causing gene variants that can be passed from one generation to another.

In ex-vivo gene therapy, the targeted cells are removed from the patient and gene therapy is administered to the cells in vitro before they are returned to the patient's body.


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