Question

Is CO binding to hemoglobin reversible?

Answer 1

Hemoglobin:

1. Hemoglobin is a conjugated protein that has four polypeptide chains joined by non-covalent bonds.
2. It contains a heme prosthetic group which is an iron-containing porphyrin derivative.
3. Its function is to bind and transport oxygen at the level of tissues.

Carboxyhemoglobin:

1. Carbon monoxide forms a permanent complex with hemoglobin called carboxyhemoglobin.
2. The binding of Carbon monoxide(CO) to hemoglobin is irreversible.
3. Carbon monoxide has 200-300 times more affinity to hemoglobin than oxygen.
4. Once bound to hemoglobin carbon monoxide hinders the transfer of oxygen molecules to hemoglobin. As a result, oxygen cannot be transferred to all the body parts resulting in a condition known as hypoxia where the person begins to lose his sense.
5. Treatment includes immediate administering of oxygen in large quantities to the patients.