Is it necessary that all mutations in genes will lead to abnormalities in child? Is there any difference between sickle cell anemia and beta- cell anemia?
Is it necessary that all mutations in genes will lead to abnormalities in child? Is there any difference between sickle cell anemia and beta- cell anemia?
Not necessarly. Mutation Can cause abnormalities.
I am giving some datas related to this below, Genes are part of the cells in your body. They store instructions for the way your body grows, looks and works. Your genes make you the way you are — they help control things like your height, the curliness of your hair and the color of your eyes. You inherit (get) genes from your parents.
Sometimes the instructions in genes change. This is called a gene change or a mutation. You can pass gene changes to your children. Sometimes a gene change can cause health conditions, like cystic fibrosis and sickle cell disease. A gene change also can cause birth defects, like heart defects. These are called single gene disorders, and they run in families. A birth defect is a health condition that is present in a baby at birth. Birth defects change the shape or function of one or more parts of the body. They can cause problems in overall health, in how the body develops or in how the body works.
SC anemia& beta cell anemia are different.
Beta cell anemia is also called thalassemia/Sickle beta thalassemia is an inherited condition that affects hemoglobin, the proteinin red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease . Affected people have a different change (mutation) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). The presence of sickle-shaped red blood cells, which often breakdown prematurely and can get stuck in blood vessels, combined with the reduction or absence of mature red blood cells leads to the many signs and symptoms of sickle beta thalassemia. Features, which may include anemia (low levels of red blood cells), repeated infections, and frequent episodes of pain, generally develop in early childhood and vary in severity depending on the amount of normal hemoglobin made. Sickle beta thalassemia is inherited in an autosomal recessive manner. Treatment is supportive and depends on the signs and symptoms present in each person.
I am giving some datas related to this below,
Genes are part of the cells in your body. They store instructions for the way your body grows, looks and works. Your genes make you the way you are — they help control things like your height, the curliness of your hair and the color of your eyes. You inherit (get) genes from your parents.
Sometimes the instructions in genes change. This is called a gene change or a mutation. You can pass gene changes to your children. Sometimes a gene change can cause health conditions, like cystic fibrosis and sickle cell disease. A gene change also can cause birth defects, like heart defects. These are called single gene disorders, and they run in families. A birth defect is a health condition that is present in a baby at birth. Birth defects change the shape or function of one or more parts of the body. They can cause problems in overall health, in how the body develops or in how the body works.
SC anemia& beta cell anemia are different.
Beta cell anemia is also called thalassemia/Sickle beta thalassemia is an inherited condition that affects hemoglobin, the proteinin red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease . Affected people have a different change (mutation) in each copy of their HBB gene: one that causes red blood cells to form a "sickle" or crescent shape and a second that is associated with beta thalassemia, a blood disorder that reduces the production of hemoglobin. Depending on the beta thalassemia mutation, people may have no normal hemoglobin (called sickle beta zero thalassemia) or a reduced amount of normal hemoglobin (called sickle beta plus thalassemia). The presence of sickle-shaped red blood cells, which often breakdown prematurely and can get stuck in blood vessels, combined with the reduction or absence of mature red blood cells leads to the many signs and symptoms of sickle beta thalassemia. Features, which may include anemia (low levels of red blood cells), repeated infections, and frequent episodes of pain, generally develop in early childhood and vary in severity depending on the amount of normal hemoglobin made. Sickle beta thalassemia is inherited in an autosomal recessive manner. Treatment is supportive and depends on the signs and symptoms present in each person.
