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Question

.......... is not permeable through cell membrane.

A
CO
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B
Glucose
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C
Glucose-6-phosphate
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D
Glutamic acid
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Solution

The correct option is C Glucose-6-phosphate
Plasma membrane is made up of lipids and proteins. It is generally permeable for lipophilic or lipid soluble compounds and does not allow free passage of water soluble or hydrophilic compounds. Also to maintain charge balance the membrane is impermeable to charged species and ions. The phosphate in glucose-6-phosphate will be charged and bears a negative charge. Hence, glucose-6-phosphate cannot readily cross the cell membrane.
So, the correct answer is 'Glucose-6-phosphate'

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