Question

Is the sickle cell allele dominant or recessive?

Answer 1

Sickle cell anaemia:

1. Sickle cell anaemia is an autosomal recessive disease that is caused by mutation in which the amino acid at the 6th position (glutamine) in beta chain of hemoglobin is replaced by valine.
2. The major characteristics of the disease are anaemia (less functional RBCs) & a tendency of red blood cells to change shape at low oxygen concentrations.
3. They tend to jam in the capillaries and small blood vessels and prevent normal blood flow.