________ is the smallest unit of matter that can take part in a chemical reaction.
Atom
Explanation of correct option:
A: Atom.
According to Dalton's atomic theory, atoms are the smallest unit of matter that can take part in a chemical reaction.
Explanation of incorrect options:
B: Molecule.
Molecules take part in chemical reactions indirectly as they are a group of atoms.
C: Compound.
These are formed by the combination of two or more different atoms.
D: Element.
Atoms of the same type join together to form an element.
Hence, option A is correct.