Question

Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

• A. Thalassemia is due to less synthesis of globin molecules
• B. Both are due to a quantitative defect in globin chain synthesis
• C. Both are due to a qualitative defect in globin chain synthesis
• D. Sickle cell anaemia is due to a quantitative problem of globin molecules

Answer 1

The correct option is A

Thalassemia is due to less synthesis of globin molecules

The correct option is A.

Explanation of the correct option:

1. Thalassemia is an inherited blood illness in which the body produces an aberrant form or an insufficient amount of hemoglobin.
2. Hemoglobin is a protein found in red blood cells that transports oxygen.
3. The condition causes a large number of red blood cells to be destroyed, resulting in anemia.
4. The globins are a superfamily of heme-containing globular proteins that are involved in oxygen binding and/or transport.
5. A shortage of beta-globin results in less functional hemoglobin.
6. Red blood cells do not form normally in the absence of adequate hemoglobin, resulting in a lack of mature red blood cells.
7. In persons with beta thalassemia, a lack of mature red blood cells causes anemia and other health concerns.

Explanation of the incorrect options:

Option B:

1. Sickle-cell anemia (a hemoglobinopathy) is a qualitative disease caused by the improper synthesis of a globin.
2. Sickle-cell anemia is due to a quantitative defect in globin chain synthesis.

Option C:

1. Thalassemia is an inherited blood illness in which the body produces an aberrant form or an insufficient amount of hemoglobin.
2. Thalassemia is a quantitative defect in globin chain synthesis.

Option D:

1. Some red blood cells in sickle cell anemia resemble sickles used to cut wheat.
2. The disease gets its name from these strangely shaped cells.
3. Sickle cell anemia is one of several genetic illnesses known collectively as sickle cell disease.
4. It alters the structure of red blood cells, which transport oxygen throughout the body.
5. Sickle-cell anemia (a hemoglobinopathy) is a qualitative disease caused by the improper synthesis of a globin.

Final answer: Thalassemia is due to less synthesis of globin molecules is the correct statement.